NONMEM

Definition

Stands for NONlinear Mixed Effects Modeling. It’s a paid program that you use to parameterize PK-PD models using mixed-effect models. It’s written in the 1970’s in FORTRAN. I think it’s interesting that when I was job searching, I saw a lot of request for knowingNONMEM. I mean I know mixed-effect models, so I just somewhat said I knew NONMEM. But basically just say you know NONMEM by going to use the R package NLMIXR2, which is an open-source version of that (kinda).

A frustrating thing, however, is that I feel like NLMIXR2 assumes you come from the NONMEM side.

Terms

Even if I’m not using NONMEM, these terms appear for NLMIXR2.

1. ID: Unique subject identifier

TIME

Continuous and relative to the first event within a subject

AMT

Amount of drug adminstered

DV

Dependent variable

EVID

Event identifier, 0 = observation, 1 = dose, 2 = other

PRED

Population-level prediction

IPRED

Individual-level prediction

###CPRED