PK-PD terms

Gist

Things that come up

PK (Pharmacokinetics)

What the body does to the drug? We’re interested in absorption, elimination, metabolism, and distribution of the body. A concentration versus time.

PD (Pharmacodynamics)

What the drug does to the body? Concentration versus effect

PK-PD

The effects over time

KA

A first-order absorption rate constant from the depot to the central compartment

Depot

Where the drug is administered

Central

Central is the primary systemic compartment with clearance CL

Allometric scaling

Handled by multiplying each base population paramter by the appropriate factor

References

1. Model development with nlmxir2